Document Type
Poster Presentation
Publication Date
4-7-2023
Date Assignment Submitted
2023
Abstract
Nicotine is a very common substance: it is a plant-produced pesticide and is frequently used as a stimulant for humans. It is toxic at high doses and can cause nicotine poisoning, which is harmful for humans and lethal in flies (Velazquez-Ulloa, 2017). Experiments have identified that nicotine exposure affects the TRPA1 chemosensory cation channel (Talavera et al., 2016; Kang et al., 2010). Previously, student data has shown that nicotine exposure extends the lifespan of TRPA1 mutant flies compared to a control group of wild type flies. TRPA1 is responsible for thermotaxis and pain reception (Neely et al., 2007). These experiments seek to find a link between exposure to nicotine and survivability of TRPA1 loss of function flies via exposure to sub-lethal concentrations of nicotine. After understanding survivability to nicotine exposure, circadian rhythm and motor activity using a DAM (Drosophila activity monitor), will be measured. TRPA1 mutant, nicotine-exposed flies are expected to survive and exhibit increased locomotion as adults compared to wild type flies.
Publisher
Lynn University
Conference/Symposium
Lynn University Student Research Symposium
Contest
Poster Presentation
City/State
Boca Raton, FL
Department
College of Arts and Sciences
Recommended Citation
Deaton, J. T., & Rowland, K. D. (2023, April 7). Nicotine exposure rescues the locomotory defects of TRPA1 loss of function flies [Poster presentation]. Lynn University Student Research Symposium, Boca Raton, FL, United States.
