https://doi.org/10.1177/026119291304100611

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Cryopreserved Human Whole Blood: A Human-Based In Vitro Immunotoxicological System

Document Type

Article

Publication Date

12-2013

Abstract

The airborne environment poses numerous human health risks, including potential exposure to particulate matter and to fungal bioaerosols with pro-inflammatory capabilities. The utility of animal models in the study of the human health effects of these exposures is often limited. This is due to the necessity for a high-throughput of samples and the high financial costs involved, as well as various associated animal welfare issues. In addition, animal models might not appropriately predict the responses of humans to pro-inflammatory stimuli. Here are discussed the recent applications of a human-based assay, the cryopreserved human whole blood system, to study the human health effects of exposures to particulate matter and to the less-studied fungal spores of higher fungi (phylum Basidiomycota or 'true mushrooms'). Evidence is provided to support the utility of the human-based assay in the fields of environmental health and medical mycology, for the evaluation of common paradigms in environmental health studies, and to highlight the potential human health effects of spores of basidiomycete fungi.

Publication

Alternatives to Laboratory Animals (ATLA)

Publisher

SAGE Publishing

Volume

41

Issue

6

Pages

483-490

Department

College of Arts and Sciences

Peer Reviewed

1

Publication History

Article first published online: December 1, 2013 Issue published: December 2013

Comments

2013 FRAME.

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