The Contributions of Previous Research on the Benefits and Future Treatments of Magnesium as an Implant Material
Document Type
Poster Presentation
Publication Date
5-3-2018
Abstract
William Hunter proposed that damaged cartilage cannot be reconstituted. There is a more extensive availability of mesenchymal stem cells (MSC’s) highlights the attractiveness of their use in cartilage regeneration. After investigating the effects of magnesium on the nuclear translocation of nuclear factor-κB (NF-κB) induced by LPS and IFN-γ in RAW 264.7 (RAW) cells to validate its anti-inflammatory mechanism as well as the investigation of the chondrogenic differentiation of human bone marrow MSCs (hBMSCs) co-cultured with activated macrophage cell-conditioned medium and the potential effects of magnesium addition in the process, the following conclusion can be drawn: The use of Magnesium showed evidence of enhancing the chondrogenic differentiation of mesenchymal stem cells by inhibiting activated macrophage-induced inflammation. Purpose: To examine the potential effects of magnesium on the phenotypic changes in
macrophages and their release of inflammatory cytokines with or without lipopolysaccharide (LPS) and interferon-γ (IFN-γ) activation.
Host
Zenodo
Conference/Symposium
Inaugural Larkin University Research Symposium
City/State
Miami, FL
Department
College of Arts and Sciences
Creative Commons License
This work is licensed under a Creative Commons Attribution-Share Alike 4.0 International License.
Recommended Citation
Sperry, Bailey; Stateman, Ariel; Sutton, Jennifer; and Rivera-Mariani, Felix, "The Contributions of Previous Research on the Benefits and Future Treatments of Magnesium as an Implant Material" (2018). Faculty and Staff Publications & Presentations. 1423.
https://spiral.lynn.edu/facpubs/1423
