Graduate Student Dissertations, Theses, Capstones, and Portfolios
Date of Award
8-2025
Document Type
Capstone
Granting Institution
Lynn University
Degree Name
Master of Science (M.S.)
Degree Program
Biological Science
Department
College of Arts and Sciences
First Advisor
Dr. Cassandra S. Korte
Abstract
Neurodegenerative diseases have emerged as a critical medical challenge because they cause progressive neuronal death alongside structural or functional deterioration. Families, healthcare institutions, and affected individuals face significant challenges due to neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases, which impair both cognitive function and motor abilities. Researchers have found that nicotine in tobacco products is a compound with therapeutic potential. This literature review explores how nicotine interacts with neurodegenerative mechanisms, such as oxidative stress and inflammation, and assesses its potential neuroprotective effects in conditions like Alzheimer's and Parkinson's diseases. In the central nervous system, nicotine binds to the nicotinic acetylcholine receptor, modulating neurological processes such as memory formation and learning. Recent research suggests that nicotine may exert neuroprotective effects by activating these receptors, potentially reducing the progression or severity of neurodegenerative diseases. This review uses previous research and clinical trials to explain these effects mechanistically, while showing their practical value for healthcare. It will illustrate essential concepts about neurodegenerative diseases as well as nicotine's pharmacological features. The paper reviews scientific findings about nicotine's activity in neural signaling pathways, evaluates its potential for therapeutic and clinical use, and discusses social and ethical implications. Furthermore, this paper reviews investigates nicotine’s dual nature by exploring its potential to protect neural function in the context of neurodegenerative diseases, while also addressing the significant risks posed by its addictive properties and adverse effects on long-term brain health.
Recommended Citation
Deaton, J. T. (2025). The role of nicotine in treating neurodegenerative diseases [Master's capstone, Lynn University]. SPIRAL. https://spiral.lynn.edu/etds/437
